Why Leptin Resistance Problem Facing Obese Women?

In obesity, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high-energy stores.

Despite of the elevated Leptin levels, obese women failing to control hunger and modulate their weight.

An important contributor to leptin resistance are: 1-changes to leptin receptors in the brain or 2-changes to the way leptin transport to the brain  may be due to high levels of triglycerides affecting the transport of leptin across the brain or due to the leptin transporter becoming saturated.or3- alterations occurring during development The reason for this Leptin resistance can be reversed when directed on a low-energy diet – Leptin Diet